Header
- Model name
- Inflammation
- Developer
- Zenlo LLC
- Release stage
- Research Tool (not FDA-cleared)
- Version
- 1.0
- Availability
- United States
- Regulatory status
- Not applicable — academic and transparency positioning
- Pattern slug
- inflammation
- Biomarkers
- HSCRP, ESR, FERR
This document follows the CHAI Applied Model Card format (v0.1).
Summary
The Inflammation pattern surfaces laboratory evidence of systemic or chronic inflammatory activity in adult panels. A deterministic detector evaluates high-sensitivity CRP, erythrocyte sedimentation rate, and ferritin against pattern-specific thresholds, with sex-aware ferritin cutoffs. Any qualifying elevation fires the pattern. An LLM-assisted narrative explains which inflammatory markers are abnormal and suggests clinical context for physician review. The tool is intended for licensed functional-medicine physicians as supportive clinical decision support — it does not distinguish infection from autoimmune or metabolic inflammation, and it does not replace targeted workup. Outputs prompt physician judgment rather than automated diagnosis.
Uses & Directions
Intended use
Clinical decision support for licensed physicians evaluating inflammatory marker patterns in adult laboratory panels.
Primary users
Licensed functional medicine physicians and similarly qualified clinicians.
How to use
Interpret flagged results alongside symptoms, medications, acute illness, and follow-up inflammatory or autoimmune testing. Physician authorization required.
Target population
Adults aged 18 and older in the United States.
Out of scope
- Direct patient use without physician oversight
- Pediatric populations
- Standalone diagnosis of specific inflammatory diseases
- Acute infection triage without clinical correlation
Warnings
Clinical risk level
Low — supportive tool; the treating physician retains full clinical judgment and responsibility.
Known limitations
- hs-CRP and ferritin are non-specific; elevations have many causes including infection, obesity, and liver disease.
- Does not differentiate acute versus chronic inflammation.
- Ferritin as an inflammatory marker overlaps semantically with iron-status interpretation.
Validation note
Validation pending — a Tier A NHANES validation run has not yet been completed for this pattern. Distribution, agreement, and fairness results will be published here when available.
Trust Ingredients
AI system facts
- Deterministic pattern detector (inflammation) plus Claude Haiku 4.5 for narrative synthesis
- Primary inputs: hs-CRP, ESR, and ferritin from structured laboratory extraction.
- Output: Pattern flag plus narrative on inflammatory marker abnormalities.
Security & compliance
- Anthropic Business Associate Agreement with zero-data-retention configuration
- HIPAA-aligned design; no patient data used for model training
Ongoing maintenance
Versioned, transparent, and reproducible via a public independent audit harness (see Resources).
Transparency
Self-funded development; no third-party sponsor for this pattern card.
Key Metrics
Usefulness / Efficacy
Zenlo's detection approach was benchmarked across five models in a separate study; see the medRxiv preprint in Resources. No per-pattern efficacy metric is published for this pattern.
Source: 5-model benchmark, medRxiv MEDRXIV/2026/346284
Fairness / Equity
Validation pending — a Tier A NHANES validation run has not yet been completed for this pattern. Distribution, agreement, and fairness results will be published here when available.
Safety / Reliability
- Supportive-only; not intended as a standalone diagnostic
- Physician authorization required before clinical use
- Deterministic detector is reproducible for inputs: HSCRP, ESR, FERR
Resources
- medRxiv preprint MEDRXIV/2026/346284 — 5-model benchmark (system-level detector evaluation)
- JAMIA Open submission JAMIO-2026-0120 (under review)
- Independent audit harness: github.com/dimashibakov/zenlo-audit — reproducibility manifest, NHANES 2015–2016 cycle, harness commit c10afe8
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