Header
- Model name
- Anemia
- Developer
- Zenlo LLC
- Release stage
- Research Tool (not FDA-cleared)
- Version
- 1.0
- Availability
- United States
- Regulatory status
- Not applicable — academic and transparency positioning
- Pattern slug
- anemia
- Biomarkers
- HGB, HCT, MCV
This document follows the CHAI Applied Model Card format (v0.1).
Summary
The Anemia pattern flags low hemoglobin, hematocrit, and/or microcytic indices in adult complete blood count panels, signaling potential anemia for physician review. Deterministic rules compare hemoglobin and hematocrit against sex-aware reference lower limits and evaluate mean corpuscular volume for microcytosis patterns. Claude Haiku 4.5 provides narrative context on which CBC indices triggered the flag. For licensed functional-medicine physicians, this is supportive clinical decision support — it does not classify anemia subtype (iron deficiency vs. B12 vs. hemolytic), assess bleeding sources, or replace hematology referral. The pattern prompts correlation with iron studies, B12/folate, reticulocyte count, and clinical symptoms.
Uses & Directions
Intended use
Clinical decision support for licensed physicians reviewing CBC indices suggestive of anemia in adult panels.
Primary users
Licensed functional medicine physicians and similarly qualified clinicians.
How to use
Correlate flagged CBC values with iron studies, B12/folate, reticulocytes, and bleeding history.
Target population
Adults aged 18 and older in the United States.
Out of scope
- Direct patient use without physician oversight
- Pediatric anemia evaluation
- Standalone diagnosis of anemia etiology
- Hemoglobinopathy or thalassemia genotyping
Warnings
Clinical risk level
Low — supportive tool; the treating physician retains full clinical judgment and responsibility.
Known limitations
- Low hemoglobin has many etiologies beyond iron deficiency.
- Does not incorporate reticulocyte count or peripheral smear review.
- Acute blood loss may not be captured in a single CBC time point.
Validation note
Validation pending — a Tier A NHANES validation run has not yet been completed for this pattern. Distribution, agreement, and fairness results will be published here when available.
Trust Ingredients
AI system facts
- Deterministic pattern detector (anemia) plus Claude Haiku 4.5 for narrative synthesis
- Primary inputs: Hemoglobin, hematocrit, and MCV with sex-aware reference comparison.
- Output: Pattern flag plus narrative on CBC abnormalities suggestive of anemia.
Security & compliance
- Anthropic Business Associate Agreement with zero-data-retention configuration
- HIPAA-aligned design; no patient data used for model training
Ongoing maintenance
Versioned, transparent, and reproducible via a public independent audit harness (see Resources).
Transparency
Self-funded development; no third-party sponsor for this pattern card.
Key Metrics
Usefulness / Efficacy
Zenlo's detection approach was benchmarked across five models in a separate study; see the medRxiv preprint in Resources. No per-pattern efficacy metric is published for this pattern.
Source: 5-model benchmark, medRxiv MEDRXIV/2026/346284
Fairness / Equity
Validation pending — a Tier A NHANES validation run has not yet been completed for this pattern. Distribution, agreement, and fairness results will be published here when available.
Safety / Reliability
- Supportive-only; not intended as a standalone diagnostic
- Physician authorization required before clinical use
- Deterministic detector is reproducible for inputs: HGB, HCT, MCV
Resources
- medRxiv preprint MEDRXIV/2026/346284 — 5-model benchmark (system-level detector evaluation)
- JAMIA Open submission JAMIO-2026-0120 (under review)
- Independent audit harness: github.com/dimashibakov/zenlo-audit — reproducibility manifest, NHANES 2015–2016 cycle, harness commit c10afe8
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